ETV6/RUNX1 FUSION GENE ABROGATION DECREASES THE ONCOGENICITY OF TUMOUR CELLS IN A PRECLINICAL MODEL OF ACUTE LYMPHOBLASTIC LEUKAEMIA

ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia.The implication of the fusion protein in leukemogenesis seems to be clear.However, its role in the maintenance of the disease continues to be controversial.Methods: Generation of

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Readability of Operational Risk Disclosures of Banks

Operational ORG SMALL RED BEANS risk has been acknowledged as a major source of material failures in financial firms.Despite the increased concern of financial institutions and their stakeholders on this topic, the literature that deals specifically with the operational risk disclosure in the banking system is scarce.The present research investigat

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The Efficiency of Alternative and Conventional Energy Exchange-Traded Funds: Are Clean Energy Exchange-Traded Funds a Safer Asset?

This paper examines the efficiency of alternative energy equity Exchange-Traded Funds (ETFs) and conventional energy equity ETFs from 2018 to 2020, utilizing a combination of an output-oriented Slack-Based Data Envelopment Firearms Analysis (DEA) model and cluster analysis.In the context of an output-oriented DEA model, efficiency is defined as the

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